Implementing Cardiogenomics in Clinical Practice

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Implementing Cardiogenomics in Clinical Practice

15 to 30-minute modules that let you practice assessing patients' risk for a genetic cardiac condition, interpreting cardiac genetic test results, and managing patients with hereditary cardiovascular disease.

developed by jax and northwestern feinberg school of medicine

Identifying Red Flags and Patterns for Hereditary Cardiovascular Disease (CME)

Identifying Red Flags and Patterns for Hereditary Cardiovascular Disease (CME)

Practice identifying genetic risk factors for cardiac disease.

Identifying Red Flags and Patterns for Hereditary Cardiovascular Disease (CNE)

Identifying Red Flags and Patterns for Hereditary Cardiovascular Disease (CNE)

Practice identifying genetic risk factors for cardiac disease.

Interpreting Positive Results from Cardiac Genetic Testing (CME)

Interpreting Positive Results from Cardiac Genetic Testing (CME)

Practice interpreting positive genetic test results to personalize patient management for hereditary cardiac disease.

Interpreting Positive Results from Cardiac Genetic Testing (CNE)

Interpreting Positive Results from Cardiac Genetic Testing (CNE)

Practice interpreting positive genetic test results to personalize patient management for hereditary cardiac disease.

Indications for Germline Testing After Genomic Tumor Testing (CME)

Indications for Germline Testing After Genomic Tumor Testing (CME)

Interpret test results to identify patients with hereditary risks.

CME Course Test selection Hereditary/germline Risk Assessment Test Interpretation Test strategy

Indications for Germline Testing After Genomic Tumor Testing (CNE)

Indications for Germline Testing After Genomic Tumor Testing (CNE)

Interpret test results to identify patients with hereditary risks.

CNE Test selection Hereditary/germline Risk Assessment Test Interpretation CNE Course Test strategy

Cancer Pretest Decisions and Counseling (CME)

Cancer Pretest Decisions and Counseling (CME)

Practice deciding when and if genetic testing is appropriate, given a patient's clinical and personal context.

CME Course Test selection Hereditary/germline Communication Test strategy

Identifying and Managing Lynch Syndrome (CNE)

Identifying and Managing Lynch Syndrome (CNE)

Practice recognizing Lynch syndrome (LS) red flags, communicating about the LS testing process, and incorporating increased screening.

CNE Hereditary/germline Risk Assessment Management CNE Course

Exploring Pharmacogenomic Testing (CNE)

Exploring Pharmacogenomic Testing (CNE)

Learn how to determine whether pharmacogenomic testing is appropriate for the patient and practice applying test results to patient management.

Collecting Family History with Sufficient Detail (CME)

Collecting Family History with Sufficient Detail (CME)

Practice asking the right questions to elicit enough information to assess family history disease risk.

CME Course Hereditary/germline Risk Assessment Communication

Categorizing Cancer Risk (CME)

Categorizing Cancer Risk (CME)

Analyze family histories and classify the patients' risk into average, increased (or moderate), or high risk for cancer.

CME Course Risk Assessment

Hereditary Cancer Syndromes: Are Your Patients at Risk?

Hereditary Cancer Syndromes: Are Your Patients at Risk?

Learn to identify those patients most appropriate for genetic testing, choosing the right test, and using the results to develop a management plan.

Test selection Hereditary/germline Risk Assessment Test Interpretation Management Communication Test strategy

Carrier Screening (CME)

Carrier Screening (CME)

Learn about the benefits and limitations of carrier screening in prenatal care.

Using Family History to Inform Management (CME)

Using Family History to Inform Management (CME)

Practice determining appropriate management for a patient based on family history risk stratification.

CME Course Hereditary/germline

Choosing the Best Genomic Tumor Test (CNE)

Choosing the Best Genomic Tumor Test (CNE)

Identify the benefits and limitations of genomic tumor test options.

Targeted Therapy CNE Test selection Test Interpretation CNE Course Test strategy Test type

Interpreting Cancer Biomarker Testing - When Is Additional Testing Needed? (CNE)

Interpreting Cancer Biomarker Testing - When Is Additional Testing Needed? (CNE)

Learn when additional cancer biomarker testing is indicated for further evaluation of genome-informed therapy

CNE Test Interpretation Logistics Management CNE Course

Interpreting Cancer Biomarker Testing - When Is Additional Testing Needed? (CME)

Interpreting Cancer Biomarker Testing - When Is Additional Testing Needed? (CME)

Learn when additional cancer biomarker testing is indicated for further evaluation of genome-informed therapy

CME Course Test Interpretation Logistics Management

Genomic Testing for the Healthy Individual (CNE)

Genomic Testing for the Healthy Individual (CNE)

Practice identifying patient motivations for genomic testing and assessing if a genomic test is a good fit.

Carrier Screening (CNE)

Carrier Screening (CNE)

Learn about the benefits and limitations of carrier screening in prenatal care.

Exome Testing for Diagnosis (CNE)

Exome Testing for Diagnosis (CNE)

Practice identifying patients who may benefit from exome testing and communicating with patients, families, and genetic experts about testing.

Exploring Cancer Biomarker Testing (CNE)

Exploring Cancer Biomarker Testing (CNE)

Learn about benefits, limitations, and challenges of using biomarker testing to inform treatment decisions for cancer patients.

Interpreting Cancer Genetic Testing Results (CME)

Interpreting Cancer Genetic Testing Results (CME)

Practice interpreting cancer genetic testing results and reports within a patient-specific context.

CME Course Hereditary/germline Test Interpretation

Choosing the Best Genomic Tumor Test (CME)

Choosing the Best Genomic Tumor Test (CME)

Identify the benefits and limitations of genomic tumor test options.

Targeted Therapy CME Course Test selection Test Interpretation Test strategy Test type

Exploring Pharmacogenomic Testing (CME)

Exploring Pharmacogenomic Testing (CME)

Learn how to determine whether pharmacogenomic testing is appropriate for the patient and practice applying test results to patient management.

Prenatal Cell-Free DNA Screening (CNE)

Prenatal Cell-Free DNA Screening (CNE)

Learn about the benefits and limitations of cell-free DNA screening in prenatal care for the purpose of facilitating patient decision-making

Multidisciplinary Expert Insights: Assessing Hereditary Cancer Risks for Genomic Tumor Testing

Multidisciplinary Expert Insights: Assessing Hereditary Cancer Risks for Genomic Tumor Testing

A multidisciplinary panel of clinical and laboratory experts discusses a case that highlights factors relevant for the interpretation of tumor results for hereditary risks.

Tumor Testing Webinar Test selection Hereditary/germline Test Interpretation Video Test strategy Test type

Genetic Testing in Pediatric Neurology (CNE)

Genetic Testing in Pediatric Neurology (CNE)

Practice identifying when further value might be added by a molecular diagnosis and choosing the best genetic tests for the clinical context.

Comparing Genetic Test Methodologies

Comparing Genetic Test Methodologies

Provides a quick reference for the detection capabilities for common types of genetic testing, such as gene sequencing and deletion/duplication analysis.

Resources Test selection Hereditary/germline Logistics Article Test strategy Test type

Financial considerations of genomic tumor testing

Financial considerations of genomic tumor testing

Help clinicians discuss costs of genomic tumor testing and targeted treatments with their patients, including ways to find financial support.

Blog Targeted Therapy Test selection Logistics

Assessing Genomic Biomarkers for Targeted Therapy Options

Assessing Genomic Biomarkers for Targeted Therapy Options

Provides a framework for assessing the evidence supporting targeted treatment options.

Targeted Therapy Test Interpretation Management Article Preparing

Genetically Related Cancers

Genetically Related Cancers

Provides key features and cancer risks associated with common hereditary cancer syndromes.

Hereditary/germline Risk Assessment Article

MUTYH-associated Polyposis

MUTYH-associated Polyposis

Describes the clinical features, diagnosis, testing and genetics of MUTYH-associated polyposis (MAP).

Test selection Hereditary/germline Risk Assessment Management Test strategy Factsheet

Three things to know about genomic tumor test selection

Three things to know about genomic tumor test selection

Discusses considerations for choosing the most appropriate genomic tumor test for a patient.

Blog Test selection Test strategy Test type

Understanding variants of uncertain significance in biomarker testing

Understanding variants of uncertain significance in biomarker testing

Describes reasons a genomic variant can have uncertain significance when identified in a tumor.

Fundamental Test Interpretation Article Preparing

Describes the clinical features, diagnosis, testing and genetics of Lynch syndrome (hereditary nonpolyposis colorectal cancer).

Hereditary/germline Risk Assessment Management Test strategy Factsheet

Comparing Cancer Biomarker Tests

Comparing Cancer Biomarker Tests

Provides information about how cancer biomarker test offerings may differ among laboratories.

Test selection Logistics Article Test strategy Test type Preparing

Liquid Biopsy: Frequently Asked Questions

Liquid Biopsy: Frequently Asked Questions

Describes the benefits, risks and limitations of liquid biopsy.

Targeted Therapy Test selection Test type FAQ Preparing

Evaluating Immune Checkpoint Inhibitor Biomarkers for Immunotherapy Options

Evaluating Immune Checkpoint Inhibitor Biomarkers for Immunotherapy Options

Provides an overview of the benefits and limitations of commonly used immune checkpoint inhibition biomarkers.

Targeted Therapy Test selection Management Article Test type Applying

Family History Collection Tips & Tools

Family History Collection Tips & Tools

Provides tips, resources, and tools for family history collection in clinical practice.

Hereditary/germline Risk Assessment Communication Article

Hereditary Cancer Panels

Hereditary Cancer Panels

Provides considerations when evaluating different multi-gene panels for hereditary cancer testing.

Test selection Hereditary/germline Test Interpretation Article Test type

Hereditary Breast & Ovarian Cancer (HBOC) Syndrome

Hereditary Breast & Ovarian Cancer (HBOC) Syndrome

Describes the clinical features, diagnosis, testing and genetics of hereditary breast and ovarian cancer (HBOC) syndrome.

Test selection Hereditary/germline Risk Assessment Management Test strategy Factsheet

Hereditary Cancer Management Guidelines

Hereditary Cancer Management Guidelines

Provides access to current management guidelines based on genetic or familial risk.

Hereditary/germline Management Article

Immunotherapy: Implications for patients with mismatch repair deficient tumors

Immunotherapy: Implications for patients with mismatch repair deficient tumors

Discussion of how precision medicine brings personalized treatment options to patients with mismatch repair deficient tumors.

Blog Targeted Therapy Hereditary/germline Management

Case #298776 (02/02/24)

Case #298776 (02/02/24)

Breast; Variants: ATM p.R3008H, PTEN p.E157*, FH p.K477dup, TET2 p.Q886*, TP53 p.M66fs

breast GTB minutes

Identifying Red Flags and Patterns that Increase Cancer Risk (CME)

Identifying Red Flags and Patterns that Increase Cancer Risk (CME)

Practice identifying genetic risk factors for cancer.

CME Course Hereditary/germline Risk Assessment

Using Family History to Inform Management (CNE)

Using Family History to Inform Management (CNE)

Practice determining appropriate management for a patient based on family history risk stratification.

CNE Hereditary/germline CNE Course

Categorizing Cancer Risk (CNE)

Categorizing Cancer Risk (CNE)

Analyze family histories and classify the patients' risk into average, increased (or moderate), or high risk for cancer.

CNE Risk Assessment CNE Course

Cancer Genetic Testing Process (CME)

Cancer Genetic Testing Process (CME)

Familiarize yourself with the steps involved in ordering genetic testing for hereditary cancer risk.

CME Course Hereditary/germline Logistics

Genetic Testing for Breast Cancer Risk (CME)

Genetic Testing for Breast Cancer Risk (CME)

Practice evaluating how well a particular genetic test assesses breast cancer risk and the potential impact of testing on patient outcomes.

CME Course Risk Assessment

Genetic Testing for Breast Cancer Risk (CNE)

Genetic Testing for Breast Cancer Risk (CNE)

Practice evaluating how well a particular genetic test assesses breast cancer risk and the potential impact of testing on patient outcomes.

CNE Risk Assessment CNE Course

Cancer Genetic Testing Process (CNE)

Cancer Genetic Testing Process (CNE)

Familiarize yourself with the steps involved in ordering genetic testing for hereditary cancer risk.

CNE Hereditary/germline Logistics CNE Course

Cancer Pretest Decisions and Counseling (CNE)

Cancer Pretest Decisions and Counseling (CNE)

Practice deciding when and if genetic testing is appropriate, given a patient's clinical and personal context.

CNE Test selection Hereditary/germline Communication CNE Course Test strategy

Identifying and Managing Lynch Syndrome (CME)

Identifying and Managing Lynch Syndrome (CME)

Practice recognizing Lynch syndrome (LS) red flags, communicating about the LS testing process, and incorporating increased screening.

CME Course Hereditary/germline Risk Assessment Management

Identifying Red Flags and Patterns that Increase Cancer Risk (CNE)

Identifying Red Flags and Patterns that Increase Cancer Risk (CNE)

Practice identifying genetic risk factors for cancer.

CNE Hereditary/germline Risk Assessment CNE Course

Interpreting Cancer Genetic Testing Results (CNE)

Interpreting Cancer Genetic Testing Results (CNE)

Practice interpreting cancer genetic testing results and reports within a patient-specific context.

CNE Hereditary/germline Test Interpretation CNE Course

Exome Testing for Diagnosis (CME)

Exome Testing for Diagnosis (CME)

Practice identifying patients who may benefit from exome testing and communicating with patients, families, and genetic experts about testing.

Talking with Patients: Shared Decision Making about Genomic Tumor Testing

Talking with Patients: Shared Decision Making about Genomic Tumor Testing

Supports clinicians when communicating about the process, benefits, and limitations associated with somatic tumor testing.

Test selection Logistics Communication Article Test type

When is pharmacogenomic testing useful in cancer care?

When is pharmacogenomic testing useful in cancer care?

Discusses utility of pharmacogenomic testing in cancer care.

Blog Test selection

Hereditary Cancer Testing: Pretest Counseling Recommendations

Hereditary Cancer Testing: Pretest Counseling Recommendations

Outlines key points to address during pretest counseling.

Test selection Hereditary/germline Communication Article

Bigger is Not Always Better: What You Should Know Before Ordering a Genomic Tumor Test

Bigger is Not Always Better: What You Should Know Before Ordering a Genomic Tumor Test

Discusses common misconceptions about genomic testing in precision oncology, provide tips for optimizing testing strategy and introduce attendees to additional educational resources.

Webinar Test selection Test strategy

S2108CD Genomic Tumor Boards Orientation

S2108CD Genomic Tumor Boards Orientation

Demonstration of what to expect in a genomic tumor board from S2108CD

Targeted Therapy Webinar Test Interpretation Management Video

Collecting Family History with Sufficient Detail (CNE)

Collecting Family History with Sufficient Detail (CNE)

Practice asking the right questions to elicit enough information to assess family history disease risk.

CNE Hereditary/germline Risk Assessment Communication CNE Course

Genomic Tumor Testing: Frequently Asked Questions

Genomic Tumor Testing: Frequently Asked Questions

Describes large-scale genomic tumor testing and discusses its benefits, risks, and limitations.

Test selection Test type FAQ

Demystifying a Genomic Tumor Test Report to Inform Patient Care

Demystifying a Genomic Tumor Test Report to Inform Patient Care

Identifies and defines key components of a genomic tumor test report using a generalized approach and design.

Resources Test Interpretation Article

Important Considerations for Germline Genetic Testing in Cancer Patients

Important Considerations for Germline Genetic Testing in Cancer Patients

Identifies genetic red flags to inform personal and family history risk assessment and genomic tumor test results that are suggestive of a germline variant.

Hereditary/germline Test Interpretation Article Test strategy

Hereditary Cancer Testing Results Interpretation

Hereditary Cancer Testing Results Interpretation

Outlines how to interpret results from cancer genetic testing in different patient situations.

Hereditary/germline Test Interpretation

How do I get from here to there? Navigating precision medicine in cancer

How do I get from here to there? Navigating precision medicine in cancer

Discusses the role of a genomics navigator to help navigate genetic and genomic testing for cancer patients.

Breast Cancer Genetic Testing Strategy: Picking the Best Multigene Panel Test for your Patient

Breast Cancer Genetic Testing Strategy: Picking the Best Multigene Panel Test for your Patient

Learn about the benefits, risks and limitations of germline multigene panels for different patients in this 15-minute video.

Webinar Test selection Hereditary/germline Risk Assessment Video Test strategy

Three things to know about DTC breast cancer genetic testing

Three things to know about DTC breast cancer genetic testing

Discusses the benefits and limitations of direct-to-consumer genetic testing for breast cancer risk

Blog Hereditary/germline Test Interpretation

Testing to Identify Genomic Variants Related to Cancer

Testing to Identify Genomic Variants Related to Cancer

This resource defines and compares benefits and limitations of type of testing: somatic, paired somatic/germline and concurrent somatic + germline.

Resources Test selection Hereditary/germline Test Interpretation Article Test type

Cancer Biomarker Report Terms

Cancer Biomarker Report Terms

Explains common terms used in cancer biomarker test reports.

Fundamental Resources Test Interpretation Article

Ordering & Interpreting PD-L1 testing

Ordering & Interpreting PD-L1 testing

Discusses which patients may benefit from PD-L1 testing and how to select and interpret tests for patients with different cancer types.

Targeted Therapy Test selection Test Interpretation Article Test strategy Test type

How to Maximize the Genomic Tumor Board Experience

How to Maximize the Genomic Tumor Board Experience

Suggests ways for you to make the most of the genomic tumor board experience.

Targeted Therapy Test Interpretation Logistics Management Article

Multidisciplinary Expert Insights: Navigating DNA Damage Repair Deficiency in Cancer Patient Management

Multidisciplinary Expert Insights: Navigating DNA Damage Repair Deficiency in Cancer Patient Management

A multidisciplinary panel of clinical experts discusses a case that involves DNA repair deficiency and PARP inhibitors, including BRCA1/2 and other biomarkers, and how to make informed decisions regarding the best path forward for the patient.

Webinar SWOG Preparing

Genomic Testing for the Healthy Individual (CME)

Genomic Testing for the Healthy Individual (CME)

Practice identifying patient motivations for genomic testing and assessing if a genomic test is a good fit.

Case #296738 (9/7/23)

Case #296738 (9/7/23)

Cholangiocarcinoma; Variants identified: PIK3CA p.E545K & p.E726G, CDK6 p.R214H

GTB minutes cholangiocarcinoma

Prenatal Cell-Free DNA Screening (CME)

Prenatal Cell-Free DNA Screening (CME)

Learn about the benefits and limitations of cell-free DNA screening in prenatal care for the purpose of facilitating patient decision-making

Genetic Testing in Pediatric Neurology (CME)

Genetic Testing in Pediatric Neurology (CME)

Practice identifying when further value might be added by a molecular diagnosis and choosing the best genetic tests for the clinical context.

Exploring Cancer Biomarker Testing (CME)

Exploring Cancer Biomarker Testing (CME)

Learn about benefits, limitations, and challenges of using biomarker testing to inform treatment decisions for cancer patients.