Interpreting Positive Results from Cardiac Genetic Testing (CME)

Genetic testing for cardiac diseases allows healthcare providers to move beyond a one-size-fits-all approach and adopt a more personalized and targeted management strategy, resulting in improved patient outcomes and quality of life. However, it is essential to interpret genetic test results accurately and in the context of the patient's clinical presentation, family history, and other relevant factors. In this course, you will practice interpreting positive genetic test results to personalize patient management for cardiac disease. This course is part of a series, Implementing Cardiogenomics in Clinical Practice.

To claim credit, follow the steps in the learning path.

CME Information and Disclosures 

Jointly Provided by The Jackson Laboratory and Northwestern University Feinberg School of Medicine Office of Continuing Medical Education.

Release Date: November 9, 2023 
Expiration Date: January 31, 2026  

Learning Objectives

• Interpret your patient’s positive genetic test results
• Use positive results to inform management for patients and their family members

Target Audience 
Practicing cardiology physicians, physician assistants, and nurses. 

Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Northwestern University Feinberg School of Medicine and The Jackson Laboratory. Northwestern University Feinberg School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.  

Credit Designation Statement
Northwestern University Feinberg School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Disclosure
FSM’s CME Leadership and Staff have nothing to disclose.

Course Director’s and Planning Committee Members Disclosure Information:
Lisa Castillo, MS, CGC - Northwestern University - Has nothing to disclose.
Kristen DeBerg, MS, CGC - Sanford Health - Has nothing to disclose.
Emily Edelman, MS, CGC - The Jackson Laboratory - Supported on grant from Pfizer Inc. (relationship has ended)
Mary Maradik, MSN, RN - Northwestern University - Has nothing to disclose.
Therese Ingram, MA - The Jackson Laboratory - Has nothing to disclose.
Kalisi Logan, MS, CGC - The Jackson Laboratory - Serves as an advisor for Igentify.
Laura Rasmussen-Torvik, PhD, MPH - Northwestern University - Has nothing to disclose.
Greg Webster, MD, MPH - Northwestern University - Has nothing to disclose.

All of the relevant financial relationships listed for these individuals have been mitigated.

This activity is being sponsored by the Feinberg School of Medicine, Department of Preventive Medicine and The Jackson Laboratory.  The medical school has no significant relationship with the commercial companies whose products are services are being discussed in this educational activity. The program does not discuss the off-labeled use of any product. 

Educational Support 
This program was supported by educational grants from the American Heart Association. There is no commercial support being received for this activity.  

References 

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm. Oct 2018;15(10):e190-e252.

Guo L, Torii S, Fernandez R, et al. Genetic Variants Associated With Unexplained Sudden Cardiac Death in Adult White and African American Individuals. JAMA Cardiol. Sep 1 2021;6(9):1013-1022.

Ho CY, Day SM, Ashley EA, et al. Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe). Circulation. Oct 2 2018;138(14):1387-1398. doi:10.1161/CIRCULATIONAHA.117.033200

Manickam K, McClain MR, Demmer LA, et al. Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). Genet Med. Nov 2021;23(11):2029-2037. 

Miller DT, Lee K, Abul-Husn NS, et al. ACMG SF v3.2 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. Aug 2023;25(8):100866. 

Ommen SR, Mital S, Burke MA, et al. 2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. Dec 22 2020;76(25):e159-e240.

Towbin JA, McKenna WJ, Abrams DJ, et al. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. Nov 2019;16(11):e373-e407.

van Rijsingen IA, Arbustini E, Elliott PM, et al. Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study. J Am Coll Cardiol. Jan 31 2012;59(5):493-500.

Hardware/Software Requirements

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Screen resolution of 800X600 or higher 
Adobe Reader 5.0 or higher 

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Should you have questions about CME approval, contact the Feinberg School of Medicine Office of Continuing Medical Education.

Disclaimer 

All information in Implementing Cardiogenomics in Clinical Practice is provided for educational purposes only. This information is not a substitute for clinical guidance or the consultation of a medical professional. Always seek the advice of a qualified health professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in Implementing Cardiogenomics in Clinical Practice. Reliance on any information in Implementing Cardiogenomics in Clinical Practice is solely at your own risk. The Jackson Laboratory does not endorse or recommend any specific procedures, tests, products, services, health professionals or other information that may be found in Implementing Cardiogenomics in Clinical Practice.