Genetic Testing for Breast Cancer Risk (CNE)

Genetic Testing for Breast Cancer Risk (CNE)

Practice evaluating how well a particular genetic test assesses breast cancer risk and the potential impact of testing on patient outcomes.

rate limit

Code not recognized.

About this course

Indications for genetic testing for breast cancer risk are expanding and patients who previously would not meet criteria for testing may now qualify based on recent guidelines. While multi-gene panels can increase the likelihood of identifying a cancer predisposition gene, there are also associated risks and limitations that should be considered by patients and providers before genetic testing. In this course, you will practice communicating these benefits, risks and limitations to support shared decision-making with your patients about engaging in multi-gene panel testing.

To claim credit, follow the steps in the learning path.


CNE Information and Disclosures

Original Release: May 3, 2017
Expiration Date: June 13, 2025

Target Audience
This activity is designed to meet the educational needs of practicing nurses and advanced practice nurses.

Learning Outcome
Identify and manage individuals at increased risk of cancer due to familial factors and hereditary cancer syndromes.

CNE Approval Statement
This nursing continuing professional development activity was approved by the Northeast Multistate Division, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

Nurses are eligible for a maximum of .25 contact hours upon the completion of this activity.

Claiming Your Credit
In order to claim credit 1) answer the pre-assessment questions, 2) work through the module content in its entirety, 3) successfully complete the post-assessment answering 2 out of 4 questions correctly and 4) complete the evaluation.   
 
Planners, Writers, and Reviewers
  • Emily Edelman, MS, CGC – The Jackson Laboratory
  • Therese Ingram, MA – The Jackson Laboratory
  • Kalisi Logan, MS, CGC – The Jackson Laboratory 
  • Kate Reed, MPH, ScM, CGC – The Jackson Laboratory 
  • Linda Steinmark, MS, CGC – The Jackson Laboratory 
  • Hayley Dunnack Yackel, PhD, RN, CMSRN, OCN – Hartford Healthcare Cancer Institute 
  • Fatima Amir, MS, CGC - Genome Medical 

Conflict of Interest Disclosure
This educational activity does not include any content that relates to the products and/or services of a commercial interest that would create a conflict of interest. Unless otherwise noted, the program planners and faculty do not have a financial interest/arrangement or affiliation with any organizations that could be perceived as a real or apparent conflict of interest in the context of the subject of this course.

Commercial Support
An earlier version of this program was supported by educational grants from The Maine Cancer Foundation and The Jackson Laboratory Director's Innovation Fund. There is no commercial support being received for this activity.

References

American College of Obstetricians and Gynecologists. Committee Opinion No. 793: Hereditary Cancer Syndromes and Risk Assessment. Obstetrics & Gynecology. 2019; 134(6):e143-e149.

Berliner JL, Cummings SA, Boldt Burnett B, Ricker CN. Risk assessment and genetic counseling for hereditary breast and ovarian cancer syndromes—Practice resource of the National Society of Genetic Counselors. J Genet Couns. 2021; 30(2):342-360.

Buys SS, Sandbach JF, Gammon A, et al. A Study of Over 35,000 Women with Breast Cancer Tested with a 25-Gene Panel of Hereditary Cancer Genes. Cancer. 2017; 123(10):1721-1730.

Couch FJ, Shimelis H, Hu C, et al. Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. JAMA Oncol. 2017; 3(9):1190-.

Desmond A, Kurian AW, Gabree M, et al. Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. JAMA Oncol. 2015; 1(7):943-.

Kurian AW, Hare EE, Mills MA, et al. Clinical Evaluation of a Multiple-Gene Sequencing Panel for Hereditary Cancer Risk Assessment. JCO. 2014; 32(19):2001-2009.

Lee K, Seifert BA, Shimelis H, et al. Clinical Validity Assessment of Genes Frequently Tested on Hereditary Breast and Ovarian Cancer Susceptibility Sequencing Panels. Genet Med. 2018; 21(7):1497-1506.

Lundy MG, Forman A, Valverde K, Kessler L. An Investigation of Genetic Counselors’ Testing Recommendations: Pedigree Analysis and the Use of Multiplex Breast Cancer Panel Testing. J Genet Counsel. 2014; 23(4):618-632.

National Comprehensive Cancer Network (NCCN). NCCN Guidelines for Detection, Prevention and Risk Reduction. (Requires free registration).

Robson ME, Bradbury AR, Arun B, et al. American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility. JCO. 2015; 33(31):3660-3667.

Theobald KA, Susswein LR, Marshall ML, et al. Utility of Expedited Hereditary Cancer Testing in the Surgical Management of Patients with a New Breast Cancer Diagnosis. Ann Surg Oncol. 2018; 25(12):3556-3562.


Hardware/Software Requirements

Audio speakers or headphones

Screen resolution of 800X600 or higher
Adobe Reader 5.0 or higher

Check the supported browsers.

Should you have technical questions or questions regarding the content of the activity, please email Clinical Education at the Jackson Laboratory.


Disclaimer

All information in Cancer Genetic Clinical Education is provided for educational purposes only. This information is not a substitute for clinical guidance or the consultation of a medical professional. Always seek the advice of a qualified health professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in Cancer Genetic Clinical Education. Reliance on any information in Cancer Genetic Clinical Education is solely at your own risk. The Jackson Laboratory does not endorse or recommend any specific procedures, tests, products, services, health professionals or other information that may be found in Cancer Genetic Clinical Education.

Learning Path

  • Pre-assessment
  • Pre-course assessment

    The pre-test is required to access the educational material.

  • Review Course Materials
  • Genetic Testing for Breast Cancer Risk

    Contains the educational material.

  • Post Quiz & Evaluation
  • Post-course assessment

    Passing the post-test is required to earn a certificate.

  • Evaluation
  • Accessing your certificate
  • Resources

    The resources and references are the same as found in the course material. 

  • Tools & resources

    Additional resources for more learning about genomic tumor testing

  • More education
  • References

    References used to develop the content

About this course

Indications for genetic testing for breast cancer risk are expanding and patients who previously would not meet criteria for testing may now qualify based on recent guidelines. While multi-gene panels can increase the likelihood of identifying a cancer predisposition gene, there are also associated risks and limitations that should be considered by patients and providers before genetic testing. In this course, you will practice communicating these benefits, risks and limitations to support shared decision-making with your patients about engaging in multi-gene panel testing.

To claim credit, follow the steps in the learning path.


CNE Information and Disclosures

Original Release: May 3, 2017
Expiration Date: June 13, 2025

Target Audience
This activity is designed to meet the educational needs of practicing nurses and advanced practice nurses.

Learning Outcome
Identify and manage individuals at increased risk of cancer due to familial factors and hereditary cancer syndromes.

CNE Approval Statement
This nursing continuing professional development activity was approved by the Northeast Multistate Division, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

Nurses are eligible for a maximum of .25 contact hours upon the completion of this activity.

Claiming Your Credit
In order to claim credit 1) answer the pre-assessment questions, 2) work through the module content in its entirety, 3) successfully complete the post-assessment answering 2 out of 4 questions correctly and 4) complete the evaluation.   
 
Planners, Writers, and Reviewers
  • Emily Edelman, MS, CGC – The Jackson Laboratory
  • Therese Ingram, MA – The Jackson Laboratory
  • Kalisi Logan, MS, CGC – The Jackson Laboratory 
  • Kate Reed, MPH, ScM, CGC – The Jackson Laboratory 
  • Linda Steinmark, MS, CGC – The Jackson Laboratory 
  • Hayley Dunnack Yackel, PhD, RN, CMSRN, OCN – Hartford Healthcare Cancer Institute 
  • Fatima Amir, MS, CGC - Genome Medical 

Conflict of Interest Disclosure
This educational activity does not include any content that relates to the products and/or services of a commercial interest that would create a conflict of interest. Unless otherwise noted, the program planners and faculty do not have a financial interest/arrangement or affiliation with any organizations that could be perceived as a real or apparent conflict of interest in the context of the subject of this course.

Commercial Support
An earlier version of this program was supported by educational grants from The Maine Cancer Foundation and The Jackson Laboratory Director's Innovation Fund. There is no commercial support being received for this activity.

References

American College of Obstetricians and Gynecologists. Committee Opinion No. 793: Hereditary Cancer Syndromes and Risk Assessment. Obstetrics & Gynecology. 2019; 134(6):e143-e149.

Berliner JL, Cummings SA, Boldt Burnett B, Ricker CN. Risk assessment and genetic counseling for hereditary breast and ovarian cancer syndromes—Practice resource of the National Society of Genetic Counselors. J Genet Couns. 2021; 30(2):342-360.

Buys SS, Sandbach JF, Gammon A, et al. A Study of Over 35,000 Women with Breast Cancer Tested with a 25-Gene Panel of Hereditary Cancer Genes. Cancer. 2017; 123(10):1721-1730.

Couch FJ, Shimelis H, Hu C, et al. Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer. JAMA Oncol. 2017; 3(9):1190-.

Desmond A, Kurian AW, Gabree M, et al. Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. JAMA Oncol. 2015; 1(7):943-.

Kurian AW, Hare EE, Mills MA, et al. Clinical Evaluation of a Multiple-Gene Sequencing Panel for Hereditary Cancer Risk Assessment. JCO. 2014; 32(19):2001-2009.

Lee K, Seifert BA, Shimelis H, et al. Clinical Validity Assessment of Genes Frequently Tested on Hereditary Breast and Ovarian Cancer Susceptibility Sequencing Panels. Genet Med. 2018; 21(7):1497-1506.

Lundy MG, Forman A, Valverde K, Kessler L. An Investigation of Genetic Counselors’ Testing Recommendations: Pedigree Analysis and the Use of Multiplex Breast Cancer Panel Testing. J Genet Counsel. 2014; 23(4):618-632.

National Comprehensive Cancer Network (NCCN). NCCN Guidelines for Detection, Prevention and Risk Reduction. (Requires free registration).

Robson ME, Bradbury AR, Arun B, et al. American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility. JCO. 2015; 33(31):3660-3667.

Theobald KA, Susswein LR, Marshall ML, et al. Utility of Expedited Hereditary Cancer Testing in the Surgical Management of Patients with a New Breast Cancer Diagnosis. Ann Surg Oncol. 2018; 25(12):3556-3562.


Hardware/Software Requirements

Audio speakers or headphones

Screen resolution of 800X600 or higher
Adobe Reader 5.0 or higher

Check the supported browsers.

Should you have technical questions or questions regarding the content of the activity, please email Clinical Education at the Jackson Laboratory.


Disclaimer

All information in Cancer Genetic Clinical Education is provided for educational purposes only. This information is not a substitute for clinical guidance or the consultation of a medical professional. Always seek the advice of a qualified health professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in Cancer Genetic Clinical Education. Reliance on any information in Cancer Genetic Clinical Education is solely at your own risk. The Jackson Laboratory does not endorse or recommend any specific procedures, tests, products, services, health professionals or other information that may be found in Cancer Genetic Clinical Education.

Learning Path

  • Pre-assessment
  • Pre-course assessment

    The pre-test is required to access the educational material.

  • Review Course Materials
  • Genetic Testing for Breast Cancer Risk

    Contains the educational material.

  • Post Quiz & Evaluation
  • Post-course assessment

    Passing the post-test is required to earn a certificate.

  • Evaluation
  • Accessing your certificate
  • Resources

    The resources and references are the same as found in the course material. 

  • Tools & resources

    Additional resources for more learning about genomic tumor testing

  • More education
  • References

    References used to develop the content